An Introduction to the Uses of Nitrofurantoin
) is a prescription antibiotic. Furadantin (the liquid form) and Macrodantin (the regular-release form) are both approved for the treatment and prevention of urinary tract infections
). Macrobid (the slow-release capsule form) is approved only to treat UTIs
, not prevent them.
How Does It Work?
Nitrofurantoin works in a unique way, compared to other antibiotics. In bacterial cells, the drug is changed into a highly reactive form that destroys certain bacterial proteins and molecules. As a result, the drug interferes with bacteria's ability to make essential cell components such as protein, DNA, and cell walls.
Nitrofurantoin Uses in Children
Furadantin and Macrodantin are approved for use in children over the age of one month. Macrobid is approved only for individuals age 12 and older. Nitrofurantoin in any form should not be given to newborns (one month and younger), due to the risk of hemolytic anemia, a potentially dangerous condition involving the destruction of red blood cells.