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Drug Interactions With Nitrofurantoin

Some of the drugs that can interact with nitrofurantoin include Probenecid, oral typhoid vaccine, and antacids containing magnesium trisilicate. Interactions with this product can affect the way your body absorbs nitrofurantoin. To reduce your risk of these and other problems, tell your healthcare provider about any other medications you are taking.

An Overview of Nitrofurantoin Drug Interactions

Nitrofurantoin (Furadantin®, Macrobid®, Macrodantin®) can potentially interact with a number of other medicines. The medications that may lead to drug interactions with nitrofurantoin include but are not limited to:
 

More Information on Interactions With Nitrofurantoin

The following sections explain in detail the potentially negative interactions that can occur when nitrofurantoin is taken with any of the drugs listed above.
 
Magnesium Trisilicate
If nitrofurantoin is taken with products containing magnesium trisilicate, your body may not absorb nitrofurantoin adequately. These medications should not be combined.
 
Norfloxacin
Nitrofurantoin may make norfloxacin less effective. In general, these medications should not be taken together.
 
Oral Typhoid Vaccine
Nitrofurantoin may decrease the effectiveness of the oral typhoid vaccine. If you are taking nitrofurantoin, your oral typhoid vaccine may need to be postponed for at least a day after finishing your nitrofurantoin prescription.
 
Probenecid
Probenecid can affect the way the kidneys handle nitrofurantoin. This can cause nitrofurantoin to build up in the bloodstream (possibly leading to toxicity) and may also make nitrofurantoin less effective.
 
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