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Understanding the Risks With Cipro XR

Specific Precautions and Warnings With Cipro XR

Some warnings and precautions to be aware prior to taking Cipro XR include the following:
  • Like all quinolones, Cipro XR may cause tendon problems, including tendon rupture. People who are over the age of 60; who have had liver, lung, or heart transplants; or who take corticosteroid drugs are at an increased risk for tendon problems.

Contact your healthcare provider right away if you have any tendon pain, soreness, or swelling, or if you experience weakness or difficulty moving any of your joints. Do not exercise until your healthcare provider makes sure you do not have a ruptured tendon. (Click Cipro XR and Tendon Rupture for more information.)  

  • Cipro XR can cause severe allergic reactions. Contact your healthcare provider immediately if you develop any signs of an allergic reaction, such as a rash or hives, itching, swelling of the lips or throat, wheezing, or difficulty breathing.
  • Central nervous system problems and neurological side effects have been reported with Cipro XR use, sometimes even after just one dose. Such problems may include:
    • Seizures
    • Tremors
    • Confusion
    • Dizziness
    • Hallucinations
    • Paranoia
    • Anxiety
    • Depression
    • Nervousness
    • Agitation
    • Nightmares
    • Suicidal thoughts or acts. 
Certain conditions (including epilepsy, cerebral arteriosclerosis, and kidney disease) can increase the risk of developing these problems. Let your healthcare provider know if you have any of these conditions before beginning treatment. 
  • Cipro XR may cause a rare and potentially dangerous heart rhythm known as QT prolongation. This problem may be more common in older adults, people with low blood potassium, or those taking certain other medications (see Cipro XR Drug Interactions).


  • Cipro XR (as well as all other fluoroquinolone antibiotics) can cause worsening of myasthenia gravis symptoms, such as muscle weakness and breathing problems. This is a serious occurrence, which can be life-threatening. In severe cases, this can result in the need to be put on a ventilator, or even death. Cipro XR should be avoided in people with a known history of myasthenia gravis


  • People with diabetes who are taking sulfonylureas may experience high or low blood sugar while taking Cipro XR (see Cipro XR Drug Interactions). If you have diabetes, you may need to monitor your blood sugar more closely while taking this medicine.
  • People taking Cipro XR may be more sensitive to the sun. Try to avoid sun exposure, including natural sun and tanning beds, during treatment. If you do go out in the sun, wear protective clothing and sunscreen. Contact your healthcare provider if you develop a severe sunburn while taking this medication.
  • Cipro XR has been reported to cause a nerve problem called peripheral neuropathy. If you develop any unusual sensations while taking this medication, such as pain, burning, tingling, prickling, or weakness, contact your healthcare provider right away to reduce the chance of permanent nerve damage.
  • You may become dizzy or lightheaded while taking Cipro XR. Therefore, you should avoid driving or doing anything that requires mental alertness until you know how you will react to this medication.
  • Cipro XR has been associated with muscle, joint, or tendon problems in children. This medication is not approved for use in children. However, if your child is taking it, contact his or her healthcare provider immediately if any muscle, joint, or tendon problems (such as weakness, soreness, or swelling) occur during or after Cipro XR use.
  • There have been rare reports of liver problems with this drug. Contact your healthcare provider immediately if you develop any signs of liver problems, such as:
    • Dark urine
    • Loss of appetite
    • Fatigue or excessive tiredness
    • Pain in the right upper part of the stomach
    • Yellowing of the whites of the eyes or skin (jaundice).
  • Antibiotics like Cipro XR can disrupt the normal bacteria in the digestive tract, allowing undesirable bacteria to overgrow. This can lead to a serious problem known as pseudomembranous colitis.

Let your healthcare provider know if you experience bloody or watery diarrhea. Although mild, short-term diarrhea is a common side effect of antibiotics, bloody or watery diarrhea may be signs of a serious, potentially life-threatening problem. This severe reaction can occur during treatment with Cipro XR, or even months after you stop taking it.  

  • Cipro XR may react with several other medications (see Cipro XR Drug Interactions).
  • Cipro XR is a pregnancy Category C medication, which means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Cipro XR and Pregnancy for more information).
  • Cipro XR passes through breast milk. Therefore, if you are breastfeeding or plan to start, check with your healthcare provider before using this drug (see Cipro XR and Breastfeeding).

Cipro XR Antibiotic Information

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