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Cipro XR Drug Interactions
Caffeine, corticosteroids, NSAIDs, and methotrexate are among the drugs that can interact with Cipro XR. As a result, the effectiveness of the medications may be reduced or you may be at an increased risk of side effects. If interactions are a concern, your healthcare provider may adjust your dosages and/or monitor you more carefully during treatment.
An Overview of Interactions With Cipro XR
Cipro® XR (ciprofloxacin extended release) is a prescription medication used to treat urinary tract infections (UTIs). This medication can potentially react with several other medications. Some of the drugs that may lead to Cipro XR drug interactions include but are not limited to:- Aluminum, calcium, or magnesium antacids (Alternagel®, Gaviscon®, Maalox®, Mylanta®, Tums®, and many others)
- Caffeine
- Corticosteroids, such as:
- Betamethasone (Celestone®)
- Cortisone
- Dexamethasone (Decadron®)
- Fludrocortisone (Florinef®)
- Hydrocortisone (Cortef®)
- Methylprednisolone (Depo-Medrol®, Medrol®)
- Prednisolone (Orapred®, Pediapred®)
- Prednisone
- Triamcinolone (Kenalog®, Aristospan®)
- Didanosine (Videx®)
- Erlotinib (Tarceva®)
- Medications that cause a certain change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications for a list of such drugs)
- Methotrexate (Rheumatrex®)
- Mycophenolate (CellCept®)
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
- Celecoxib (Celebrex®)
- Diclofenac (Cambia™, Cataflam®, Flector®, Solaraze® Gel, Voltaren®, Voltaren® Gel, Voltaren®-XR, Voltaren Ophthalmic®, Zipsor™)
- Etodolac (Lodine®, Lodine® XL)
- Ibuprofen (Motrin®, Advil®, Nuprin®)
- Indomethacin (Indocin®, Indocin SR®)
- Ketoprofen (Orudis®, Actron®, Oruvail®)
- Ketorolac (Toradol®)
- Meloxicam (Mobic®)
- Nabumetone (Relafen®)
- Naproxen (Naprosyn®) or naproxen sodium (Aleve®, Anaprox®, Naprelan®)
- Oxaprozin (Daypro®)
- Piroxicam (Feldene®)
- Others (see List of NSAIDs for a more complete list of these drugs)
- P-glycoprotein inducers, such as:
- Carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®)
- Dexamethasone (Decadron®)
- Doxorubicin (Adriamycin®, Doxil®)
- Nefazodone (Serzone®)
- Prazosin (Minipress®)
- Rifampin (Rifadin®)
- St. John's wort
- Tipranavir (Aptivus®)
- Trazodone (Desyrel®) and trazodone ER (Oleptro™)
- Vinblastine
- P-glycoprotein inhibitors, such as:
- Amiodarone (Cordarone®, Pacerone®)
- Atorvastatin (Lipitor®, also found in Caduet®)
- Carvedilol (Coreg®, Coreg CR®)
- Clarithromycin (Biaxin®)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Darunavir (Prezista®)
- Dipyridamole (Persantine®, also found in Aggrenox®)
- Dronedarone (Multaq®)
- Erythromycin
- Grapefruit juice
- Itraconazole (Sporanox®)
- Ketoconazole (Nizoral®)
- Lapatinib (Tykerb®)
- Lopinavir and ritonavir (Kaletra®)
- Mefloquine (Lariam®)
- Nelfinavir (Viracept®)
- Nicardipine (Cardene®)
- Nilotinib (Tasigna®)
- Progesterone
- Propranolol (Inderal®, Inderal LA®, InnoPran XL®, also found in Inderide®)
- Quinidine
- Ranolazine (Ranexa®)
- Reserpine
- Ritonavir (Norvir®, also found in Kaletra®)
- Saquinavir (Invirase®)
- Sunitinib (Sutent®)
- Tacrolimus (Prograf®, Protopic®)
- Tamoxifen (Nolvadex®)
- Verapamil (Calan®, Calan SR®, Covera-HS®, Isoptin SR®, Verelan®, Verelan PM®)
- Pentoxifylline (Trental®)
- Phenytoin (Phenytek®, Dilantin®)
- Probenecid
- Quinapril (Accupril®) or quinapril-hydrochlorothiazide (Accuretic®, Quinaretic®)
- Ropinirole (Requip®) and ropinirole XL (Requip® XL)
- Sevelamer (Renagel®, Renvela®)
- Sucralfate (Carafate®)
- Sulfonylureas (or sulfonylurea combination medications), such as:
- Chlorpropamide (Diabinese®)
- Glimepiride (Amaryl®)
- Glimepiride and pioglitazone (Duetact®)
- Glimepiride and rosiglitazone (Avandaryl®)
- Glipizide (Glucotrol®, Glucotrol XL®)
- Glipizide and metformin (Metaglip®)
- Glyburide (DiaBeta®, Micronase®, Glynase®)
- Glyburide and metformin (Glucovance®)
- Tolazamide (Tolinase®)
- Tolbutamide (Orinase®)
- Theophylline (Uniphyl®, Theochron®, TheoCap®, Theo-24®, Elixophyllin®)
- Tizanidine (Zanaflex®)
- Typhoid vaccine
- Vitamins or supplements that contain aluminum, calcium, magnesium, zinc, or iron
- Warfarin (Coumadin®, Jantoven®).
Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD