Cipro XR Drug Interactions

Caffeine, corticosteroids, NSAIDs, and methotrexate are among the drugs that can interact with Cipro XR. As a result, the effectiveness of the medications may be reduced or you may be at an increased risk of side effects. If interactions are a concern, your healthcare provider may adjust your dosages and/or monitor you more carefully during treatment.

• Aluminum, calcium, or magnesium antacids (Alternagel^®, Gaviscon^®, Maalox^®, Mylanta^®, Tums^®, and many others)
• Caffeine
• Corticosteroids, such as:
   
  • Betamethasone (Celestone^®)
  • Cortisone
  • Dexamethasone (Decadron^®)
  • Fludrocortisone (Florinef^®)
  • Hydrocortisone (Cortef^®)
  • Methylprednisolone (Depo-Medrol^®, Medrol^®)
  • Prednisolone (Orapred^®, Pediapred^®)
  • Prednisone
  • Triamcinolone (Kenalog^®, Aristospan^®)

• Didanosine (Videx^®)
• Erlotinib (Tarceva^®)
• Medications that cause a certain change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications for a list of such drugs)
• Methotrexate (Rheumatrex^®)
• Mycophenolate (CellCept^®)
• Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
   
  • Celecoxib (Celebrex^®)
  • Diclofenac (Cambia™, Cataflam^®, Flector^®, Solaraze^® Gel, Voltaren^®, Voltaren^® Gel, Voltaren^®-XR, Voltaren Ophthalmic^®, Zipsor™)
  • Etodolac (Lodine^®, Lodine^® XL)
  • Ibuprofen (Motrin^®, Advil^®, Nuprin^®)
  • Indomethacin (Indocin^®, Indocin SR^®)
  • Ketoprofen (Orudis^®, Actron^®, Oruvail^®)
  • Ketorolac (Toradol^®)
  • Meloxicam (Mobic^®)
  • Nabumetone (Relafen^®)
  • Naproxen (Naprosyn^®) or naproxen sodium (Aleve^®, Anaprox^®, Naprelan^®)
  • Oxaprozin (Daypro^®)
  • Piroxicam (Feldene^®)
  • Others (see List of NSAIDs for a more complete list of these drugs)

• P-glycoprotein inducers, such as:
   
  • Carbamazepine (Carbatrol^®, Epitol^®, Equetro^®, Tegretol^®)
  • Dexamethasone (Decadron^®)
  • Doxorubicin (Adriamycin^®, Doxil^®)
  • Nefazodone (Serzone^®)
  • Prazosin (Minipress^®)
  • Rifampin (Rifadin^®)
  • St. John's wort
  • Tipranavir (Aptivus^®)
  • Trazodone (Desyrel^®) and trazodone ER (Oleptro™)
  • Vinblastine

• P-glycoprotein inhibitors, such as:
   
  • Amiodarone (Cordarone^®, Pacerone^®)
  • Atorvastatin (Lipitor^®, also found in Caduet^®)
  • Carvedilol (Coreg^®, Coreg CR^®)
  • Clarithromycin (Biaxin^®)
  • Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
  • Darunavir (Prezista^®)
  • Dipyridamole (Persantine^®, also found in Aggrenox^®)
  • Dronedarone (Multaq^®)
  • Erythromycin
  • Grapefruit juice
  • Itraconazole (Sporanox^®)
  • Ketoconazole (Nizoral^®)
  • Lapatinib (Tykerb^®)
  • Lopinavir and ritonavir (Kaletra^®)
  • Mefloquine (Lariam^®)
  • Nelfinavir (Viracept^®)
  • Nicardipine (Cardene^®)
  • Nilotinib (Tasigna^®)
  • Progesterone
  • Propranolol (Inderal^®, Inderal LA^®, InnoPran XL^®, also found in Inderide^®)
  • Quinidine
  • Ranolazine (Ranexa^®)
  • Reserpine
  • Ritonavir (Norvir^®, also found in Kaletra^®)
  • Saquinavir (Invirase^®)
  • Sunitinib (Sutent^®)
  • Tacrolimus (Prograf^®, Protopic^®)
  • Tamoxifen (Nolvadex^®)
  • Verapamil (Calan^®, Calan SR^®, Covera-HS^®, Isoptin SR^®, Verelan^®, Verelan PM^®)

• Pentoxifylline (Trental^®)
• Phenytoin (Phenytek^®, Dilantin^®)
• Probenecid
• Quinapril (Accupril^®) or quinapril-hydrochlorothiazide (Accuretic^®, Quinaretic^®)
• Ropinirole (Requip^®) and ropinirole XL (Requip^® XL)
• Sevelamer (Renagel^®, Renvela^®)
• Sucralfate (Carafate^®)
• Sulfonylureas (or sulfonylurea combination medications), such as:
   
  • Chlorpropamide (Diabinese^®)
  • Glimepiride (Amaryl^®)
  • Glimepiride and pioglitazone (Duetact^®)
  • Glimepiride and rosiglitazone (Avandaryl^®)
  • Glipizide (Glucotrol^®, Glucotrol XL^®)
  • Glipizide and metformin (Metaglip^®)
  • Glyburide (DiaBeta^®, Micronase^®, Glynase^®)
  • Glyburide and metformin (Glucovance^®)
  • Tolazamide (Tolinase^®)
  • Tolbutamide (Orinase^®)

• Theophylline (Uniphyl^®, Theochron^®, TheoCap^®, Theo-24^®, Elixophyllin^®)
• Tizanidine (Zanaflex^®)
• Typhoid vaccine
• Vitamins or supplements that contain aluminum, calcium, magnesium, zinc, or iron
• Warfarin (Coumadin^®, Jantoven^®).